Blar i forfatter "Hughes, David J."

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    • Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort 

      Butt, Julia; Jenab, Mazda; Werner, Jill; Fedirko, Veronika; Weiderpass, Elisabete; Dahm, Christina C.; Tjønneland, Anne; Olsen, Anja; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Kaaks, Rudolf; Turzanski-Fortner, Renée; Aleksandrova, Krasimira; Schulze, Matthias B.; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosaria; Sacerdote, Carlotta; Bueno-De-Mesquita, Bas; van Gils, Carla H.; Gram, Inger Torhild; Lukic, Marko; Sala, Núria; Sánchez Pérez, Maria José; Ardanaz, Eva; Chirlaque, Maria-Dolores; Palmquist, Richard; Löwenmark, Thyra; Travis, Ruth C.; Heath, Alicia K.; Cross, Amanda J.; Freisling, Heinz; Zouiouich, Semi; Aglago, Elom; Waterboer, Tim; Hughes, David J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-20)
      Experimental evidence has implicated genotoxic <i>Escherichia coli (E. coli)</i> and enterotoxigenic <i>Bacteroides fragilis</i> (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of <i>E. coli</i> and ETBF exposure with odds of developing CRC in the European Prospective Investigation ...

    • Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status 

      Fedirko, Veronika; Jenab, Mazda; Méplan, Catherine; Jones, Jeb S.; Zhu, Wanzhe; Schomburg, Lutz; Siddiq, Afshan; Hybsier, Sandra; Overvad, Kim; Tjønneland, Anne; Omichessan, Hanane; Perduca, Vittorio; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Katzke, Verena; Aleksandrova, Krasimira; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Agnoli, Claudia; Naccarati, Alessio; Bueno-De-Mesquita, Bas; Vermeulen, Roel C.H.; Weiderpass, Elisabete; Skeie, Guri; Nøst, Therese Haugdahl; Lujan-Barroso, Leila; Quirós, Jose Ramón; Huerta, José María; Rodríguez-Barranco, Miguel; Barricarte, Aurelio; Gylling, Björn; Harlid, Sophia; Bradbury, Kathryn Erica; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc J.; Murphy, Neil; Freisling, Heinz; Tsilidis, Kostas; Aune, Dagfinn; Riboli, Elio; Hesketh, John E.; Hughes, David J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-25)
      Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants in 154 genes ...

    • Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans 

      Stepien, Magdalena; Hughes, David J.; Hybsier, Sandra; Bamia, Christina; Tjønneland, Anne; Overvad, Kim; Affret, Aurélie; His, Mathilde; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kühn, Tilman; Aleksandrova, Krasimira; Trichopoulou, Antonia; Lagiou, Pagona; Orfanos, Phlippos; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Weiderpass, Elisabete; Lasheras, Cristina; Bonet Bonet, Catalina; Molina-Portillo, Elena; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Ohlsson, Bodil; Sjöberg, Klas; Werner, Mårten; Shungin, Dmitry; Wareham, Nick; Khaw, Kay-Tee; Travis, Ruth C.; Freisling, Heinz; Cross, Amanda J.; Schomburg, Lutz; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-02)
      Background:<br>Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.<br>Methods:<br>A nested ...

    • Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study 

      Aglago, Elom K.; Mayén, Ana-Lucia; Knaze, Viktoria; Freisling, Heinz; Fedirko, Veronika; Hughes, David J.; Jiao, Li; Eriksen, Anne Kirstine; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Palli, Domenico; Sieri, Sabina; de Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, Bas; Derksen, Jeroen W.G.; Skeie, Guri; Gram, Inger Torhild; Sandanger, Torkjel M; Quirós, J. Ramón; Lujan-Barroso, Leila; Sánchez, Maria-Jose; Amiano, Pilar; Chirlaque, María-Dolores; Barricarte, Aurelio; Johansson, Ingegerd; Manjer, Jonas; Perez-Cornago, Aurora; Weiderpass, Elisabete; Gunter, Marc; Heath, Alicia K.; Schalkwijk, Casper G.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective ...

    • Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer 

      Mao, Ziling; Aglago, Elom K.; Zhao, Zhiwei; Schalkwijk, Casper C; Jiao, Li; Freisling, Heinz; Weiderpass, Elisabete; Hughes, David J.; Eriksen, Anne Kirstine; Tjønneland, Anne; Gianluca, Severi; Rothwell, Joseph A; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kaaks, Rudolf; Birukov, Anna; Schulze, Matthias B; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Bueno-De-Mesquita, Bas; Vermeulen, Roel C.H.; Gram, Inger Torhild; Skeie, Guri; Sandanger, Torkjel M; Quiros, J Ramon; Crous-Bou, Marta; Sanchez, Maria-Jose; Amiano, Pilar; Chirlaque, Maria-Dolores; Barricarte Gurrea, Aurelio; Manjer, Jonas; Johansson, Ingegerd; Perez-Cornago, Aurora; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence ...

    • Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study 

      Aglago, Elom K.; Cross, Amanda J.; Riboli, Elio; Fedirko, Veronika; Hughes, David J.; Fournier, Agnes; Jakszyn, Paula; Freisling, Heinz; Gunter, Marc J.; Dahm, Christina C.; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Srour, Bernard; Schulze, Matthias B.; Wittenbecher, Clemens; Palli, Domenico; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquita, Bas; Derksen, Jeroen W. G.; Skeie, Guri; Jensen, Torill; Lukic, Marko; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Barricarte, Aurelio; Ericson, Ulrika; van Guelpen, Bethany; Papier, Keren; Knuppel, Anika; Casagrande, Corinne; Huybrechts, Inge; Heath, Alicia K.; Tsilidis, Konstantinos K.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-09)
      Background - Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.<p> <p>Methods - We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the ...

    • Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study 

      Aglago, Elom K.; Schalkwijk, Casper G.; Freisling, Heinz; Fedirko, Veronika; Hughes, David J.; Jiao, Li; Dahm, Christina C.; Olsen, Anja; Tjønneland, Anne; Katzke, Verena; Johnson, Theron; Schulze, Matthias B.; Aleksandrova, Krasimira; Masala, Giovanna; Sieri, Sabina; Simeon, Vittorio; Tumino, Rosario; Macciotta, Alessandra; Bueno-De-Mesquita, Bas; Skeie, Guri; Gram, Inger Torhild; Sandanger, Torkjel M; Jakszyn, Paula; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Barricarte, Aurelio; Perez-Cornago, Aurora; Mayén, Ana-Lucia; Weiderpass, Elisabete; Gunter, Marc J.; Heath, Alicia K.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-29)
      Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case–control study nested within a large European cohort. Plasma ...

    • Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort 

      Stepien, Magdalena; Jenab, Mazda; Freisling, Heinz; Becker, Niels-Peter; Czuban, Magdalena; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; Savoye, Isabelle; Katzke, Verena; Kühn, Tilman; Boeing, Heiner; Iqbal, Khalid; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Weiderpass, Elisabete; Merino, Susana; Jakszyn, Paula; Sánchez, María-José; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Boden, Stina; van Guelpen, Behany; Wareham, Nick; Khaw, Kay-Tee; Bradbury, Kathryn E.; Cross, Amanda J.; Schomburg, Lutz; Hughes, David J. (Journal article; Tidsskriftartikkel; Peer reviewed; Preprint; Manuskript, 2017-07-01)
      Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective ...

    • Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study 

      Hughes, David J.; Schomburg, Lutz; Jenab, Mazda; Biessy, Carine; Méplan, Catherine; Moskal, Aurelie; Sun, Qian; Demircan, Kamil; Fedirko, Veronika; Weiderpass Vainio, Elisabete; Mukhtar, Maryam; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Schulze, Matthias; Nøst, Therese Haugdahl; Skeie, Guri; Olsen, Karina Standahl; Ricceri, Fulvio; Grioni, Sara; Palli, Domenico; Masala, Giovanna; Tumino, Rosario; Pasanisi, Fabrizio; Amiano, Pilar; Colorado Yohar, Sandra M.; Agudo, Antonio; Sánchez, Maria-Jose; Ardanaz, Eva; Sund, Malin; Andersson, Anne; Perez-Cornago, Aurora; Travis, Ruth; Heath, Alicia K.; Dossus, Laure (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-01)
      Selenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3), in ...

    • Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a 1 case-control study nested within a European prospective cohort 

      Aglago, Elom K.; Rinaldi, Sabina; Freisling, Heinz; Jiao, Li; Hughes, David J.; Fedirko, Veronika; Schalkwijk, Casper C; Weiderpass, Elisabete; Dahm, Christina C.; Overvad, Kim; Eriksen, Anne Kirstine; Kyrø, Cecilie; Boutron-Ruault, Marie-Christine; Rothwell, Joseph A.; Severi, Gianluca; Katzke, Verena; Kuhn, Tilman; Schulze, Matthias B.; Krasimira, Aleksandrova; Masala, Giovanna; Krogh, Vittorio; Panico, Salavatore; Tumino, Rosario; Naccarati, Alessio; Bueno-De-Mesquita, Bas; van Gils, Carla H.; Sandanger, Torkjel M; Gram, Inger Torhild; Skeie, Guri; Quiros, J. Ramon; Jakszyn, Rachel; Sanchez, Maria-Jose; Amiano, Pilar; Huerta, Jose Maria; Ardanaz, Eva; Johansson, Ingegerd; Harlid, Sophia; Perez-Cornago, Aurora; Mayén, Ana-Lucia; Cordova, Reynalda; Gunter, Marc J.; Vineis, Paolo; Cross, Amanda J.; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-20)
      <p>Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. <p>Methods: To investigate whether sRAGE and related genetic variants are ...

    • Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations 

      Fedirko, Veronika; Mandle, Hannah B.; Zhu, Wanzhe; Hughes, David J.; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno-de-Mesquita, Hendrik Bastiaan; van Duijnhoven, Fränzel J.B.; Siersema, Peter D.; Tjønneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala, Núria; Barricarte, Aurelio; Sánchez, María-José; Quirós, Ramón; Amiano, Pilar; Gylling, Björn; Harlid, Sophia; Perez-Cornago, Aurora; Heath, Alicia K.; Tsilidis, Konstantinos K.; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc J.; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
      Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...